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Hyperforin dicyclohexylammonium salt

CAS No. 238074-03-8

Hyperforin dicyclohexylammonium salt( Hyperforin DCHA )

Catalog No. M21824 CAS No. 238074-03-8

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Hyperforin dicyclohexylammonium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator.
  • Description
    Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect.
  • In Vitro
    Western Blot Analysis Cell Line:HaCaT cells Concentration:0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α Incubation Time:2 hours Result:Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.
  • In Vivo
    Animal Model:IMQ-induced psoriasis-like mice modelDosage:5 mg/kg Administration:Intraperitoneal injection; once daily for 7 days Result:Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation.Suppressed infiltration of CD3+ T cells and down regulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.
  • Synonyms
    Hyperforin DCHA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    238074-03-8
  • Formula Weight
    718.1
  • Molecular Formula
    C??H??NO?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL (69.63 mM; Need ultrasonic)
  • SMILES
    CC(C)C([C@@]12[C@@](C)([C@H](C[C@](C/C=C(C)/C)(C(C(C/C=C(C)/C)=C2O)=O)C1=O)C/C=C(C)/C)CC/C=C(C)/C)=O.C3(CCCCC3)NC4CCCCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Heiser JH, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem. 2013 Nov;127(3):303-13. 2. Pochwat B, et al. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice. Front Mol Neurosci. 2018 Dec 12;11:456.
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